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Current Issue vol. 26, No. 7, 2015, p. 1313-1531

 

Thoughts about the Chemistry of Natural Products

Plants and other living organisms have been used as sources of different products for long time. The understanding that the use of traditional medicine could lead to compounds for the treatment of many diseases opened an avenue for the investigation and discovery of new drugs from plants.
This approach generated a number of wonderful examples that can illustrate how plant-derived products became medicines.
Although, for a long time, most of the discovered drugs have had their origin on plants, more recently the isolation of new natural products from different organisms has opened opportunities in drug discovery. Frequently, natural products are not used as they occur in nature, but become the inspiration for the development of structurally modified new ones with more druggability.

(Read more at Editorial)


Cover Article
J. Braz. Chem. Soc. 2015, 26(7), 1357-1366

Synthesis and Evaluation of Thiazolyl-1H-benzo[d]imidazole Inhibitors of Mycobacterium tuberculosis Inosine Monophosphate Dehydrogenase

Kenia Pissinate; Diana Carolina Rostirolla; Laura Miranda Pinheiro; Priyanka Suryadevara; Perumal Yogeeswari; Dharmarajan Sriram; Luiz Augusto Basso; Pablo Machado; Diógenes Santiago Santos

How to cite this article

Using an orthologue-based approach, we synthesized and assayed a series of thiazolyl-1H-benzo[d]imidazole derivatives as inhibitors of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (MtIMPDH). From these experiments, a benzo[d]imidazole compounds was described to inhibit the enzyme in the low micromolar range, which places this compound among the most potent in vitro MtIMPDH inhibitors developed to date. Details are presented in the Article Synthesis and Evaluation of Thiazolyl-1H-benzo[d]imidazole Inhibitors of Mycobacterium tuberculosis Inosine Monophosphate Dehydrogenase by Kenia Pissinate, Diana Carolina Rostirolla, Laura de Miranda Pinheiro, Priyanka Suryadevara, Perumal Yogeeswari, Dharmarajan Sriram, Luiz Augusto Basso, Pablo Machado, and Diógenes Santiago Santos on page 1357.

http://dx.doi.org/10.5935/0103-5053.20150104

Published online: April 30, 2015
Editorial J. Braz. Chem. Soc. 2015, 26(7), 1313-1314

Thoughts about the Chemistry of Natural Products

Paulo Cezar Vieira

How to cite this article

 

http://dx.doi.org/10.5935/0103-5053.20150153

Communication J. Braz. Chem. Soc. 2015, 26(7), 1315-1320

Kinetic Parameters of Soot Oxidation Catalyzed by Nanosized ZnO-CeO2 Solids

Leandro F. Nascimento; Paulo C. de Sousa Filho; Juliana F. Lima; Osvaldo A. Serra

How to cite this article

 

CeO2 based catalysts are used for the determination of the activation parameters on the soot combustion reaction.

http://dx.doi.org/10.5935/0103-5053.20150098

Published online: April 24, 2015
Articles J. Braz. Chem. Soc. 2015, 26(7), 1321-1330

Ethanolysis Optimisation of Jupati (Raphia taedigera Mart.) Oil to Biodiesel Using Response Surface Methodology

Leyvison R. V. da Conceição; Carlos E. F. da Costa; Geraldo N. da Rocha Filho; Edenir R. Pereira-Filho; José R. Zamian

How to cite this article

 

The synthesis process of biodiesel using acid oil (jupati oil), ethanol, and acid catalyst has been optimised employing experimental design and response surface methodology.

http://dx.doi.org/10.5935/0103-5053.20150097

Published online: April 24, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1331-1337

Biological Activity Studies on Metal Complexes of Macrocyclic Schiff Base Ligand: Synthesis and Spectroscopic Characterization

Parveez Gull; Athar Adil Hashmi

How to cite this article

 

The present work shows the coordination chemistry of CoII, CuII and NiII complexes and the synthesized macrocyclic ligand. The mononuclear complexes were characterized by various spectroscopic techniques. In the search of new antimicrobial agents, these complexes were screened in vitro for their antimicrobial activities and the effect of the central metal attached in these complexes and the macrocyclic ligand were compared.

http://dx.doi.org/10.5935/0103-5053.20150099

Published online: April 24, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1338-1343

Comparative Study of First-Derivative Spectrophotometry and High Performance Liquid Chromatography Methods for Quantification of Paclitaxel in Liposomal Formulation

Marcos V. Barbosa; Liziane O. F. Monteiro; Andréa R. Malagutti; Mônica C. Oliveira; Alvaro D. Carvalho-Junior; Elaine A. Leite

How to cite this article

 

A new derivative spectrophotometric method was developed, validated, and compared to HPLC for the determination of PTX in a liposomal formulation.

http://dx.doi.org/10.5935/0103-5053.20150100

Published online: April 28, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1344-1350

Fast Microwave-Assisted Resolution of (±)-Cyanohydrins Promoted by Lipase from Candida antarctica

Sandra S. Ribeiro; Irlon M. Ferreira; João P. F. Lima; Bruno A. de Sousa; Rafaela C. Carmona; Alcindo A. Dos Santos; André L. M. Porto

How to cite this article

 

Enzymatic kinetic resolution (EKR) of (±)-cyanohydrins was performed by using immobilized lipase from Candida antarctica (CALB) under conventional ordinary conditions (orbital shaking) and under microwave radiation (MW). Under the latter experimental conditions, good performance and shorter reactions times were achieved.

http://dx.doi.org/10.5935/0103-5053.20150102

Published online: April 28, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1351-1356

Determination of Adulterants in Diesel by Integration of LED Fluorescence Spectra

Marilena Meira; Cristina M. Quintella; Erika M. O. Ribeiro; Humbervânia R. G. Silva; Alexandre K. Guimarães; Saionara Luna; Weidson L. Silva; Irlane J. de Brito

How to cite this article

 

A simple and rapid methodology for determining the content of adulterants in diesel and biodiesel-diesel blends by integration of fluorescence spectra.

http://dx.doi.org/10.5935/0103-5053.20150103

Published online: April 30, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1357-1366

Synthesis and Evaluation of Thiazolyl-1H-benzo[d]imidazole Inhibitors of Mycobacterium tuberculosis Inosine Monophosphate Dehydrogenase

Kenia Pissinate; Diana Carolina Rostirolla; Laura Miranda Pinheiro; Priyanka Suryadevara; Perumal Yogeeswari; Dharmarajan Sriram; Luiz Augusto Basso; Pablo Machado; Diógenes Santiago Santos

How to cite this article

 

Using the knowledge obtained from the orthologous enzyme, a series of thiazolyl-1H-benzo[d]imidazole derivatives was synthesized and assayed as inhibitors of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (MtIMPDH).

http://dx.doi.org/10.5935/0103-5053.20150104

Published online: April 30, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1367-1378

MCM-41 for Meloxicam Dissolution Improvement: in vitro Release and in vivo Bioavailability Studies

Asaad F. Hassan; Sally A. Helmy; Ahmed Donia

How to cite this article

 

MCM-41 was used for poorly water soluble meloxicam (MLX) as model drug. The in vitro release of MLX was performed at pH 1.2 and 6.8.

http://dx.doi.org/10.5935/0103-5053.20150105

Published online: April 30, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1379-1386

Chemometric Study of the Antiproliferative Activity of Some New Hydantoin Derivatives: Assessment of Activity and Chromatographic Lipophilicity Data

Tatjana Lj. Djaković Sekulić; Adam Smoliński; Nemanja P. Trisović; Gordana S. Usćumlić; Biljana Dj. Bozić

How to cite this article

 

Chemometric approach to the study of antiproliferative activity of newly synthesized hydantoins.

http://dx.doi.org/10.5935/0103-5053.20150106

Published online: April 30, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1387-1395

Comparison between Ultraviolet and Infrared Spectroscopies for the Simultaneous Multivariate Determination of Pyrantel and Praziquantel

Mário S. Piantavini; Flávia L. D. Pontes; Leandro X. Weiss; Marcelo M. Sena; Roberto Pontarolo

How to cite this article

 

Ultraviolet-partial least squares (UV-PLS) and diffuse reflectance infrared Fourier transform spectroscopy-PLS (DRIFT-PLS) methods for the simultaneous quantification of two veterinary pharmaceutical drugs pyrantel pamoate (PP) and praziquantel (PZ) in commercial tablets and capsules.

http://dx.doi.org/10.5935/0103-5053.20150107

Published online: May 5, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1396-1404

Efficient Synthesis of Rhodanine-Based Amides via Passerini Reaction using Tetramethylguanidine-Functionalized Silica Nanoparticles as Reusable Catalyst

Robabeh Baharfar; Razieh Azimi; Sheida Barzegar; Mojtaba Mohseni

How to cite this article

 

The efficient synthesis of novel rhodanine-based amide derivatives via Passerini reaction using tetramethylguanidine-functionalized silica nanoparticles as a reusable heterogeneous base catalyst, and the antibacterial activity of the synthesized compounds are described.

http://dx.doi.org/10.5935/0103-5053.20150108

Published online: May 5, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1405-1410

Polymerization of Ethylene with Zirconocene Heterogenized on Spherical ZSM-5

Cristiano Favero; Marcelo L. Mignoni; Roberto F. de Souza; Katia Bernardo-Gusmão

How to cite this article

 

Metallocene was heterogenized on spherical ZSM-5 zeolite and employed in ethylene polymerization reactions.

http://dx.doi.org/10.5935/0103-5053.20150109

Published online: May 5, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1411-1430

Characterization of the Volatile Profile of Brazilian Moscatel Sparkling Wines Through Solid Phase Microextraction and Gas Chromatography

Karine P. Nicolli; Juliane E. Welke; Mayara Closs; Elina B. Caramão; Gustavo Costa; Vitor Manfroi; Claudia A. Zini

How to cite this article

 

Two-dimensional gas chromatography showed superior potential compared to one-dimensional gas chromatography for the characterization of Brazilian Moscatel sparkling wines, which showed a homogeneous volatile signature.

http://dx.doi.org/10.5935/0103-5053.20150110

Published online: May 5, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1431-1437

Simple Methods via Mid-IR or 1H NMR Spectroscopy for the Determination of the Iodine Value of Vegetable Oils

Gustavo G. Shimamoto; Martha M. A. Favaro; Matthieu Tubino

How to cite this article

 

Two methods for determining the iodine value in vegetable oils are described. One employs mid-infrared spectroscopy and the other uses hydrogen nuclear magnetic resonance.

http://dx.doi.org/10.5935/0103-5053.20150111

Published online: May 5, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1438-1449

Polycyclic Aromatic Hydrocarbons in Superficial Sediments of the Negro River in the Amazon Region of Brazil

Hilton M. L. Souza; Satie Taniguchi; Márcia C. Bícego; Luiz A. Oliveira; Tereza C. S. Oliveira; Hiléia S. Barroso; Sandra P. Zanotto

How to cite this article

 

The profile and the concentration of the polycyclic aromatic hydrocarbons (PAHs) were determined in samples of superficial sediments of the Rio Negro in the Amazon region of Brazil.

http://dx.doi.org/10.5935/0103-5053.20150112

Published online: May 5, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1450-1456

Ursane Saponins from the Stems of Firmiana simplex and their Cytotoxic Activity

Kyeong Wan Woo; Sang Un Choi; Ki Hyun Kim; Kang Ro Lee

How to cite this article

 

Several ursane triterpene derivatives were isolated from the stems of Firmiana simplex. Their cytotoxic activity was evaluated against lung adenocarcinoma (A549), ovarian cancer (SK-OV-3), skin melanoma (SK-MEL-2), and colon cancer (HCT-15) cell lines using the sulforhodamine (SRB) bioassay.

http://dx.doi.org/10.5935/0103-5053.20150113

Published online: May 5, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1457-1465

Microwave-Assisted Synthesis of β-1,2,3-Triazolyl-α-amino Esters

Amna N. Khan; Stanley N. S. Vasconcelos; Gonzalo Carrau; Hélio A. Stefani

How to cite this article

 

A method for obtaining triazole units from alkynyl amino esters via click chemistry using a variety organic azides.

http://dx.doi.org/10.5935/0103-5053.20150114

Published online: May 8, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1466-1474

Poly(vinyl alcohol)-hyaluronic Acid Membranes for Wound Dressing Applications: Synthesis and in vitro Bio-Evaluations

Alaa Fahmy; Elbadawy A. Kamoun; Raafat El-Eisawy; Esmail M. El-Fakharany; Tarek H. Taha; Basem K. El-Damhougy; Farag Abdelhai

How to cite this article

 

Stepwise design and discussed bio-evaluations of poly(vinyl alcohol)-hyaluronic acid (PVA-HA) hydrogel membranes for wound dressing applications.

http://dx.doi.org/10.5935/0103-5053.20150115

Published online: May 8, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1475-1481

Application of Ultrasound-Assisted Emulsification Microextraction Based on Applying Low Density Organic Solvents to the Extraction and Determination of Mononitrotoluenes in Water Samples

Manoochehr Bahmaei; Hossein Ali Mashayekhi; Faezeh Khalilian

How to cite this article

 

In this study, simple and efficient ultrasound-assisted emulsification microextraction based on applying low density organic solvents combined was developed for the preconcentration and determination of mononitrotoluenes in water samples.

http://dx.doi.org/10.5935/0103-5053.20150116

Published online: May 8, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1482-1490

Polytetrafluorethylene Membrane-Based Liquid Three-Phase Micro Extraction Combined with in situ Differential Pulse Anodic Stripping Voltammetry for the Determination of Cadmium Ions Using Au-Nanoparticles Sol-Gel Modified Pt-Wire

Aliasghar Ensafi; Ali R. Allafchian; Behzad Rezaei

How to cite this article

 

In situ pulse anodic stripping voltamettry and polytetrafluorethylene membrane-based liquid three-phase micro extraction is presented for the micro extraction and quantification of cadmium(II) ions in trace levels. The obtained calibration curve was in the range of 1.0-250 nmol L-1 CdII with a limit of detection of 0.1 nmol L-1.

http://dx.doi.org/10.5935/0103-5053.20150117

Published online: May 8, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1491-1499

Determination of Cellulose Crystallinity of Banana Residues Using Near Infrared Spectroscopy and Multivariate Analysis

Magale K. D. Rambo; Márcia M. C. Ferreira

How to cite this article

 

Two different methods using diffractograms were used to calculate the crystalline content using near-infrared spectroscopy (NIRS) and chemometrics.

http://dx.doi.org/10.5935/0103-5053.20150118

Published online: May 12, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1500-1508

Synthesis of Dithiocarbamates by Markovnikov Addition Reaction in PEG and Their Application in Amidoalkylation of Naphthols and Indoles

Azim Ziyaei Halimehjani; Arefeh Dadras; Meraj Ramezani; Elham V. Shamiri; Seyyed E. Hooshmand; Mohammad M. Hashemi

How to cite this article

 

Synthesis of dithiocarbamates by Markovnikov addition reaction in polyethylene glycol (PEG) and their application in amidoalkylation of naphthols and indoles is reported in this manuscript.

http://dx.doi.org/10.5935/0103-5053.20150119

Published online: May 12, 2015

J. Braz. Chem. Soc. 2015, 26(7), 1509-1519

Catalytic Ozonation Using Fe2+ in the Treatment of Dairy Effluent in a Semi-Batch Process with Recycle

Raquel A. Messias; Hélcio J. I. Filho; Guilherme A. Ferreira; Otávio A. Silva; Adriano F. Siqueira; Marco A. K. Alcântara

How to cite this article

 

Dairy effluent treatment through the catalytic ozonation using Fe2+ in a semi-batch process with recycle, proposed new reactor.

http://dx.doi.org/10.5935/0103-5053.20150120

Published online: May 12, 2015
J. Braz. Chem. Soc. 2015, 26(7), 1520-1526

Surfactant-Assisted Preparation of FeCu Catalyst for Fischer-Tropsch Synthesis

Cailian Ma; Yilong Chen; Jiangang Chen

How to cite this article

 

Different surfactants have a significant effect on the morphology of catalysts and their active phase. Addition of polyvinyl alcohol (PVA) in catalyst preparation is favorable for the formation of a loosely packed microstructure and more iron carbide. Therefore, the catalyst prepared with PVA exhibits high performance of Fischer-Tropsch synthesis.

http://dx.doi.org/10.5935/0103-5053.20150121

Published online: May 15, 2015
Short Report J. Braz. Chem. Soc. 2015, 26(7), 1527-1531

A New Biflavonoid from Schinopsis brasiliensis (Anacardiaceae)

Manuela P. Cardoso; Luciano S. Lima; Juceni P. David; Bruno O. Moreira; Edlene O. Santos; Jorge M. David; Clayton Q. Alves

How to cite this article

 

The new biflavanone (2R*,3R*,2''R*,3''R*)-7-hydroxy-4'-methoxy-flavanone-(3→3'')-3''',7''-dihydroxy-4'''-methoxy-flavanone was isolated from the stems of Schinopsis brasiliensis (Anacardiaceae), and showed weak inhibition of acetyl and butyrylcholinesterase enzymes.

http://dx.doi.org/10.5935/0103-5053.20150101

Published online: April 28, 2015

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
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